Mahi Keerthana, 9, and Chandana, 8, were killed on the spot, and four other students suffered grievous injuries when a shed in New Century Public School in Vivekananda Nagar Colony in Kukatpally collapsed on Thursday evening when a class was in progress.
Two teachers of the school were also reportedly injured.
The school staff immediately rushed all the injured children to a hospital.
Locals said that the shed crashed onto the classroom due to heavy rain on Wednesday night.
The school management remained silent over the incident.