Two youths were grievously injured when a DCM van speeding in the wrong route rammed into a bike near pillar no A-659 close to the water tank stand at Hyderguda in Kukatpally.
The condition of the one of the two is stated to be critical.
Upon receipt of the information, the Kukatpally police rushed to the spot and shifted the injured to the hospital, and registered a case.
The driver of the van was absconding, the police said.