Shamshabad head constable D Vijay Kumar was killed instantly when the police patrol vehicle he was in was struck by an overspeeding lorry at Shamshabad in Ranga Reddy district at midnight on Saturday.
Three other constables sustained serious injuries and were rushed for emergency treatment, a police officer said.
The accident occurred near the SVR Function Hall on the Shapur highway.
According to the officer, the incident took place while a team of constables was checking vehicles on the highway. A high-speed lorry rammed into the police patrol van, killing Kumar on the spot. Other constables immediately transported the injured colleagues to a hospital, where the attending doctor reported that the condition of one of them was critical.
The police have taken the lorry driver into custody and are questioning him.